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Separation Systems for Commercial Biotechnology

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Separation Systems for Commercial Biotechnology (report) Commercial biotechnology separations are experiencing a surge of activity, with entire disciplines developing around some techniques.

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INTRODUCTION	XVII
REASON FOR DOING THE STUDY	XVII
STUDY GOALS AND OBJECTIVES	XVII
THE CONTRIBUTION OF THIS STUDY AND FOR WHOM IT IS INTENDED	XVII
SCOPE AND FORMAT OF THE REPORT	XVIII
METHODOLOGY AND INFORMATION SOURCES	XVIII
BCC WORK CREDENTIALS	XVIII
RELATED BCC REPORTS	XVIII
BCC ON-LINE SERVICES	XIX
DISCLAIMER	XX
SUMMARY	XXI
SUMMARY TABLE: U.S. SEPARATIONS FOR BIOTECHNOLOGY MARKET VALUE, THROUGH 2008 ($ MILLIONS)	XXII
SUMMARY FIGURE: U.S. SEPARATIONS FOR BIOTECHNOLOGY MARKET VALUE, THROUGH 2008 ($ MILLIONS)	XXIII
OVERVIEW OF BIOTECHNOLOGY SEPARATIONS	1
MARKET VALUE	1
FIGURE 1 U.S. BIOTECH SEPARATIONS MARKET SHARES BY GEOGRAPHICAL REGION, 2003 (%)	2
TABLE 1 U.S. BIOTECH SEPARATIONS MARKET VALUE BY GEOGRAPHICAL REGION, 2003	3
FIGURE 2 U.S. BIOTECH SEPARATIONS MARKET SHARES BY TYPE, 2003	4
TABLE 2 U.S. BIOTECH SEPARATIONS MARKET VALUE BY TYPE, 2003	4
LIQUID CHROMATOGRAPHY	5
FIGURE 3 U.S. BIOTECH LC TECHNIQUES MARKET SHARES BY TYPE, 2003	5
TABLE 3 U.S. BIOTECH LC TECHNIQUES MARKET VALUE BY TYPE, 2003 ($ MILLIONS)	6
CENTRIFUGATION	6
FIGURE 4 U.S. BIOTECH CENTRIFUGATION MARKET SHARES BY TYPE, 2003 (%)	7
TABLE 4 U.S. BIOTECH CENTRIFUGATION MARKET VALUE BY TYPE, 2003 ($ MILLIONS)	8
MEMBRANE FILTRATION	8
FIGURE 5 U.S. BIOTECH MEMBRANE FILTRATION MARKET SHARES BY TYPE, 2003	9
TABLE 5 U.S. BIOTECH MEMBRANE FILTRATION MARKET VALUEBY TYPE, 2003 ($ MILLIONS)	9
ELECTROPHORESIS	10
FIGURE 6 U.S. BIOTECH ELECTROPHORESIS MARKET SHARES BY TYPE, 2003 (%)	10
TABLE 6 U.S. BIOTECH ELECTROPHORESIS MARKET VALUE BY TYPE, 2003 ($ MILLIONS)	11
NICHE TECHNOLOGIES	11
FIGURE 7 U.S. BIOTECH NICHE SEPARATION TECHNOLOGIES MARKET SHARES BY TYPE, 2003 (%)	12
TABLE 7 U.S. BIOTECH MISCELLANEOUS MARKET VALUE BY TYPE, 2003 ($ MILLIONS)	13
MOLECULAR SEPARATIONS	13
SEPARATION STEPS IN BIOSEPARATIONS	14
FIGURE 8 GENERAL SCHEME OF A BIOTECH SEPARATION	15
STEPS IN PROCESSING BIOLOGICALS	15
TABLE 8 PROCESSING STEPS AND TECHNIQUES	16
STRUCTURE OF THE INDUSTRY	16
REGULATORY ENVIRONMENT	17
LIQUID CHROMATOGRAPHY IN BIOTECHNOLOGY	18
MARKET VALUE	18
TABLE 9 U.S. MARKET VALUE FOR LIQUID CHROMATOGRAPHY USED IN BIOTECHNOLOGY, THROUGH 2008 ($ MILLIONS)	19
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY	19
Ion Exchange Chromatography	19
Hydroxyapatite Chromatography	20
Size Exclusion Chromatography	20
THIN LAYER CHROMATOGRAPHY	20
AFFINITY CHROMATOGRAPHY	21
OTHERS	21
VARIABLES	22
TABLE 10 CHROMATOGRAPHIC VARIABLES	22
COMPONENTS	23
MODES	24
FIGURE 9 U.S. MARKET SHARES OF BIOTECH CHROMATOGRAPHY MODES, 2003 (%)	24
TABLE 11 U.S. BIOTECH CHROMATOGRAPHY MODES MARKET VALUE, 2003 ($ MILLIONS)	25
Process Development	25
FIGURE 10 U.S. MARKET SHARES OF BIOTECH LC PROCESS DEVELOPMENTS, 2003	26
TABLE 12 U.S. BIOTECH LC PROCESS DEVELOPMENTS MARKET VALUE, 2003 ($ MILLIONS)	27
Analytical-Scale	27
Preparative-Scale	27
Process-Scale	27
APPLICATIONS	28
FIGURE 11 U.S. MARKET SHARES OF BIOTECH CHROMATOGRAPHIC APPLICATIONS, 2003	28
TABLE 13 U.S. BIOTECH CROMATOGRAPHIC APPLICATIONS MARKET VALUE, 2003 ($ MILLIONS)	29
PROTEINS	29
Protein Purification	30
Proteinaceous Aggregates	30
Protein Recovery	30
Multimeric Proteins	30
Protein Fractionation	31
Therapeutic Proteins	31
Nucleic Acids	31
DNA Sequencing	31
Mutated DNA	32
DNA Triple Repeat Sequences	33
Polynucleotide Separations	33
SNP Separations	33
Oligonucleotide Purification	33
Trace Aggregations	34
Peptides	34
ANTIBODIES	34
Monoclonal Antibodies	34
Antibody Proteins	35
OTHERS	35
Enzymes	36
Hormones	36
Enantiomers	36
Mirror-Image Isomers	36
Racemate Mixtures	37
Virus Particles	37
Endotoxin Reduction	37
Gene Therapy	38
Drug Screening	38
Blood Substitute	39
STRUCTURE OF THE INDUSTRY	39
FIGURE 12 U.S. MARKET SHARES OF BIOTECH CHROMATOGRAPHY SUPPLIERS, 2003 (%)	40
TABLE 14 U.S. BIOTECH CHROMATOGRAPHY SUPPLIERS MARKET VALUE, 2003 ($ MILLIONS)	40
MAJOR PLAYERS	41
Agilent Technologies, Inc.	41
Applied Biosystems Group	41
Gilson	42
Waters Corp.	42
MID-LEVEL PLAYERS	42
Amersham Biosciences, Inc.	43
Analtech	43
Beckman Coulter, Inc.	44
Cohesive Technologies, Inc.	44
Bio-Rad Laboratories	45
Dionex	45
Eksigent Technologies	46
Isco, Inc.	46
Michrom Bioresources, Inc.	46
PDR-Chiral, Inc.	47
PerkinElmer, Inc.	47
Richard Scientific	47
Rohm and Haas Co.	48
Shimadzu Scientific Instruments	48
Transgenomic, Inc.	48
Varian, Inc.	49
Alltech Associates, Inc.	49
Biotage	50
Burdick & Jackson	50
Chiral Technologies, Inc.	50
Ciphergen Biosystems, Inc.	51
Davison Chemicals	51
Grace Vydac	51
Hamilton Co.	52
Hitachi, Ltd.	52
Hodge Bioseparation, Ltd.	52
Interaction Chromatography	53
Integrated Separation Systems	53
Ligochem	53
Mettler-Toledo Instruments, Inc.	54
Millipore Corp.	54
Pall Corp.	54
Phenomenex, Inc.	55
Prolinx, Inc.	55
Restek Corp.	55
Sartorius Corp.	56
Selerity Technologies, Inc.	56
Sterogene Bioseparations, Inc.	56
Supelco	57
Thermo Hypersil-Keystone	57
Tosoh Biosep LLC	57
UOP, LLC	58
Upchurch Scientific	58
Zirchrom Separations, Inc.	58
CENTRIFUGATION IN BIOTECHNOLOGY	59
MARKET VALUE	59
TABLE 15 U.S. BIOTECH CENTRIFUGATION MARKET VALUE, THROUGH 2008 ($ MILLIONS)	60
SMALL-SCALE	60
LARGE-SCALE	61
APPLICATIONS	61
FIGURE 13 U.S. MARKET SHARE OF BIOTECH CENTRIFGUATION APPLICATIONS, 2003 (%)	62
TABLE 16 U.S. BIOTECH CENTRIFUGAL APPLICATIONS MARKET VALUE, 2003 ($ MILLIONS)	62
FERMENTATION ISOLATIONS	63
Dewatering	63
Cell Separations	63
Cell Debris Removal	63
Bacterial Cells	64
Whole Cells	64
Animal Cells	64
Cell Suspensions	64
BLOOD FRACTIONATION	65
RESTRICTION FRAGMENTS RECOVERY	65
DNA Fragment Isolations	65
Plasmids	66
Large Fragments	66
Subcellular Particles	66
OTHERS	66
STRUCTURE OF THE INDUSTRY	67
FIGURE 14 U.S. MARKET SHARE OF U.S. BIOTECH CENTRIFUGE SUPPLIERS, 2003	67
TABLE 17 U.S. BIOTECH CENTRIFUGE SUPPLIERS MARKET VALUE, 2003 ($ MILLIONS)	68
MAJOR PLAYERS	68
Alfa Laval, Inc.	68
Beckman Coulter, Inc.	69
Brinkmann Instruments, Inc.	69
Kendro Laboratory Products, Inc.	70
MID-LEVEL PLAYERS	70
Bird Machine Co.	70
Fiberlite Centrifuge, Inc.	71
Fisher Scientific International, Inc.	71
Jouan, Inc.	72
LW Scientific, Inc.	72
Thermo Forma	72
MEMBRANE FILTRATION IN BIOTECHNOLOGY	73
MARKET VALUE	73
TABLE 18 U.S. MARKET VALUE OF MEMRANE FILTRATION IN BIOTECHNOLOGY, THROUGH 2008 ($ MILLIONS)	74
ULTRAFILTRATION	75
MICROFILTRATION	75
PROCESS SIZES	76
TABLE 19 PROGRESSIVE STEPS FOR MEMBRANE SCALE-UP	76
FIGURE 15 U.S. MARKET SHARE OF MEMBRANE FILTRATION PROCESS SIZES, 2003 (%)	77
TABLE 20 U.S. MARKET VALUE OF MEMBRANE FILTRATION PROCESS SIZES, 2003 ($ MILLIONS)	77
OPERATING MODES OF OPERATION	78
FIGURE 16 U.S. MARKET SHARE OF MEMBRANE FILTRATION OPERATING MODES, 2003 (%)	79
TABLE 21 U.S. MARKET VALUE OF MEMBRANE FILTRATION OPERATING MODES, 2003 ($ MILLIONS)	79
MEMBRANE CONFIGURATIONS	80
FIGURE 17 U.S. MARKET SHARE OF MEMBRANE FILTRATION CONFIGURATIONS, 2003 (%)	81
TABLE 22 U.S. MEMBRANE FILTRATION CONFIGURATIONS MARKET VALUE, 2003 ($ MILLIONS)	81
TABLE 23 CONFIGURATION ADVANTAGES IN BIOTECHNOLOGY	82
APPLICATIONS	83
FIGURE 18 U.S. MARKET SHARE OF MEMBRANE FILTRATION, BY PROCESSING TYPE, 2003 (%)	83
TABLE 24 U.S. MARKET VALUE OF MEMBRANE FILTRATION, BY PROCESSING TYPE, 2003 ($ MILLIONS)	84
UPSTREAM	84
DOWNSTREAM PROCESSING	84
Cell Separations	85
Concentration	85
Mammalian Cell Concentrations	85
Harvesting	85
Culture	86
Protein Separations	86
Blotting	87
Electrostatic Self-Assembly	87
STRUCTURE OF THE INDUSTRY	88
FIGURE 19 U.S. MARKET SHARE OF BIOTECH MEMBRANE FILTRATION SUPPLIERS, 2003 (%)	88
TABLE 25 U.S. MARKET VALUE OF MEMBRANE FILTRATION BIOTECH SUPPLIERS TIERS, 2003 ($ MILLIONS)	89
MAJOR PLAYERS	89
Millipore Corp.	89
Pall Corp.	90
MID-LEVEL PLAYERS	90
Amersham Biosciences	91
Cuno, Inc.	91
GE Osmonics, Inc.	91
Koch Membranes, Inc.	92
S&S Microsciences	92
OTHER SUPPLIERS	92
Applied Membrane Technology	93
CeraMem Separations	93
Corning, Inc.	93
Desalination Systems, Inc.	94
Minntech Corp.	94
Sartorius Corp.	94
Spectrum Laboratories, Inc.	94
ELECTROPHORESIS	95
MARKET VALUE	95
TABLE 26 U.S. MARKET VALUE OF ELECTROPHORESIS IN BIOTECHNOLOGY, THROUGH 2008 ($ MILLIONS)	96
GEL/SLAB ELECTROPHORESIS PRINCIPLES	96
FIGURE 20 SCHEMATIC OF AN ELECTROPHORESIS SEPARATION CELL	97
CAPILLARY ELECTROPHORESIS	98
ELECTROPHORETIC MODES	98
ZONE	98
TWO DIMENSIONAL	99
ISOELECTRIC FOCUSING	99
MOVING BOUNDARY	99
FREE-FLOW/OPEN-CHAMBER-FLOW, OPEN-CHAMBER	100
ISOTACHOPHORESIS	100
DIFFERENCE GEL	100
CAPILLARY GEL	101
Combined Modes	101
Capillary Electrochromatography	101
Micellar Electrokinetic Capillary Chromatography	102
Other Combinations	102
APPLICATIONS	102
FIGURE 21 U.S. MARKET SHARE OF BIOTECH ELECTROPHORESIS APPLICATIONS, 2003 (%)	103
TABLE 27 U.S. BIOTECH ELECTROPHORESIS APPLICATIONS MARKET VALUE, 2003 ($ MILLIONS)	103
DNA SEQUENCING	104
DNA Fragments	104
RDNA-Derived Products	105
DNA Fingerprinting	105
Crime-Scene Analysis	105
Non-Sequencing	106
Short Tandem Repeats	106
SNP Detection	106
Restriction Mapping	107
PROTEINS	107
Multiple Protein Fractions	107
Liquid-Phase Protein Separation	107
Expressed Proteins	108
Peptides	108
OTHERS	108
Antibodies	108
Chromosomes	109
ALP Isoenzymes	109
Gene Therapy	109
STRUCTURE OF THE INDUSTRY	109
FIGURE 22 U.S. MARKET SHARE OF BIOTECH ELECTROPHORESIS SUPPLIERS, 2003 (%)	110
TABLE 28 U.S. BIOTECH ELECTROPHORESIS SUPPLIERS MARKET VALUE, 2003 ($ MILLIONS)	111
MAJOR PLAYERS	111
Amersham Biosciences	111
Applied Biosystems	112
Beckman Coulter, Inc.	112
Bio-Rad	113
MID-LEVEL PLAYERS	113
Agilent Technologies, Inc.	113
Caliper Technologies	114
Invitrogen Corp.	114
Spectrumedix	115
Tecan, Inc.	115
SUPPLIERS	115
Apogee Designs, Ltd.	115
CuraGen Corp.	116
Diversified Biotech	116
Genomics Solutions, Inc.	116
Dionex Corp.	117
Gradipore, Inc.	117
Hitachi Chemical Co., Ltd.	117
Lynx Therapeutics, Inc.	118
MicroSolv Technology Corp.	118
Millipore Corp.	118
Phenomenex, Inc.	119
PerkinElmer, Inc.	119
NICHE BIOTECH SEPARATION TECHNOLOGIES	120
TABLE 29 U.S. MARKET VALUE OF NICHE BIOTECH SEPARATION TECHNOLOGIES, THROUGH 2008 ($ MILLIONS)	120
MICROARRAYS	120
MARKET VALUE	121
TABLE 30 U.S. MARKET VALUE OF BIOTECH MICROARRAY SEPARATIONS, THROUGH 2008 ($ MILLIONS)	122
APPLICATIONS	122
Nucleic Acids	122
DNA Sequencing	122
DNA Fingerprinting	123
Forensic Analysis	123
Oligonucleotide-based Probes	123
Proteins	124
Macromolecular Sequencing	124
Protein Expression Profiling	125
HIS-Tagged Protein Capture	125
SARS Biomarkers	125
Others	125
STRUCTURE OF THE INDUSTRY	126
Affymetrix, Inc.	126
Agilent Technologies, Inc.	126
Alpha Innotech Corp.	127
Amersham Biosciences	127
Applied Biosystems Group	127
Biomicro Systems, Inc.	128
Biosite, Inc.	128
Bruker Daltonics, Inc.	128
Caliper Technologies	129
Ciphergen Biosystems, Inc.	129
Illumina, Inc.	130
Micronics, Inc.	130
Nanogen, Inc.	130
Panomics, Inc.	131
PerkinElmer, Inc.	131
Phylos, Inc.	131
SemiBio Technology, Inc.	132
SomaLogic, Inc.	132
Tecan Boston	132
Thermo Orion	133
UT-Battelle, LLC	133
LC/MS HYBRIDS	133
MARKET VALUE	134
TABLE 31 U.S. MARKET VALUE OF BIOTECH LC/MS HYBRID SYSTEMS, THROUGH 2008 ($ MILLIONS)	134
APPLICATIONS	135
Proteins	135
Post-Translational Proteins	135
Fractions	135
Antibodies	136
Plague Pathology	136
Monitoring Bioprocesses	136
Drug Profiling	136
STRUCTURE OF THE INDUSTRY	137
Advion Biosciences, Inc.	137
Agilent Technologies, Inc.	137
Amersham Biosciences	138
Applied Biosystems Group	138
Bruker Daltonics, Inc.	139
Cetek Corp.	139
Cohesive Technologies, Inc.	139
Gilson, Inc.	139
Jeol USA	140
Kionix, Inc.	140
Rheodyne, L.P.	140
Shimadzu Scientific Instruments	141
Thermo Finnigan	141
Varian, Inc.	142
Waters Corp.	142
SPINNING SYSTEMS	142
MARKET VALUE	143
TABLE 32 U.S. MARKET VALUE OF BIOTECH SPINNING SYSTEMS, THROUGH 2008 ($ MILLIONS)	143
APPLICATIONS	144
STRUCTURE OF THE INDUSTRY	144
Corning, Inc.	145
Labconco Corp.	145
Millipore Corp.	146
Orbital Biosciences, LLC	146
Pall Life Sciences	146
Schleicher and Schuell Biosciences, Inc.	147
SpinTek Systems	147
Thermo Savant	147
Vivascience, Inc.	148
Whatman	148
MAGNETIC SYSTEMS	148
MARKET VALUE	149
TABLE 33 U.S. MARKET VALUE OF BIOTECH MAGNETIC SEPARATIONS, THROUGH 2008 ($ MILLIONS)	149
APPLICATIONS	149
Proteins	150
Cells	150
Stem Cells	150
Antibodies/Antigens	151
STRUCTURE OF THE INDUSTRY	151
Aviva Biosciences, Inc.	151
Bangs Laboratories, Inc.	152
Cortex Biochem, Inc.	152
Dynal Biotech	152
Gerstel, Inc.	153
Polysciences, Inc.	153
Promega Corp.	153
Roche Applied Sciences	154
Rocky Mountain Biosystems, Inc.	154
SUPERCRITICAL FLUID CHROMATOGRAPHY	154
TABLE 34 TYPICAL SFC MOBILE PHASES	154
MARKET VALUE	155
TABLE 35 U.S. MARKET VALUE OF BIOTECH SFC, THROUGH 2008 ($ MILLIONS)	155
APPLICATIONS	155
STRUCTURE OF THE INDUSTRY	156
Mettler-Toledo Instruments, Inc.	156
The Lavipharm Group	156
Ontogen Corp.	157
Selerity Technologies, Inc.	157
Thar Technologies, Inc.	157
APPENDICES	158
A: MOLECULAR SEPARATIONS IN BIOTECHNOLOGY	158
TABLE 36 SELECTED MOLECULAR SEPARATIONS NEEDED IN BIOTECHNOLOGY	158
TABLE 36 (CONTINUED)	159
TABLE 36 (CONTINUED)	160
B: COMMON MATERIALS IN BIOLOGICAL FEED STREAMS	160
TABLE 37 APPARENT DIMENSIONS OF SMALL PARTICLES	160
LIST OF TABLES
SUMMARY TABLE:
U.S. SEPARATIONS FOR BIOTECHNOLOGY MARKET VALUE, THROUGH 2008 ($ MILLIONS)	XXII
TABLE 1 U.S. BIOTECH SEPARATIONS MARKET VALUE, BY GEOGRAPHICAL REGION, 2003	3
TABLE 2 U.S. BIOTECH SEPARATIONS MARKET VALUE, BY TYPE, 2003	4
TABLE 3 U.S. BIOTECH LC TECHNIQUES MARKET VALUE, BY TYPE, 2003 ($ MILLIONS)	6
TABLE 4 U.S. BIOTECH CENTRIFUGATION MARKET VALUE, 2003 ($ MILLIONS)	8
TABLE 5 U.S. BIOTECH MEMBRANE FILTRATION MARKET VALUE, 2003 ($ MILLIONS)	9
TABLE 6 U.S. BIOTECH ELECTROPHORESIS MARKET VALUE, 2003 ($ MILLIONS)	11
TABLE 7 U.S. BIOTECH MISCELLANEOUS MARKET VALUE, 2003 ($ MILLIONS)	13
TABLE 8 PROCESSING STEPS AND TECHNIQUES	16
TABLE 9 U.S. MARKET VALUE FOR LIQUID CHROMATOGRAPHY USED IN BIOTECHNOLOGY, THROUGH 2008 ($ MILLIONS)	19
TABLE 10 CHROMATOGRAPHIC VARIABLES	22
TABLE 11 U.S. BIOTECH CHROMATOGRAPHY MODES MARKET VALUE, 2003 ($ MILLIONS)	25
TABLE 12 U.S. BIOTECH LC PROCESS DEVELOPMENTS MARKET VALUE, 2003 ($ MILLIONS)	27
TABLE 13 U.S. BIOTECH CROMATOGRAPHIC APPLICATIONS MARKET VALUE, 2003 ($ MILLIONS)	29
TABLE 14 U.S. BIOTECH CHROMATOGRAPHY SUPPLIERS MARKET VALUE, 2003 ($ MILLIONS)	40
TABLE 15 U.S. BIOTECH CENTRIFUGATION MARKET VALUE, THROUGH 2008 ($ MILLIONS)	60
TABLE 16 U.S. BIOTECH CENTRIFUGAL APPLICATIONS MARKET VALUE, 2003 ($ MILLIONS)	62
TABLE 17 U.S. BIOTECH CENTRIFUGE SUPPLIERS MARKET VALUE, 2003 ($ MILLIONS)	68
TABLE 18 U.S. MARKET VALUE OF MEMRANE FILTRATION IN BIOTECHNOLOGY, THROUGH 2008 ($ MILLIONS)	74
TABLE 19 PROGRESSIVE STEPS FOR MEMBRANE SCALE-UP	76
TABLE 20 U.S. MARKET VALUE OF MEMBRANE FILTRATION PROCESS SIZES, 2003 ($ MILLIONS)	77
TABLE 21 U.S. MARKET VALUE OF MEMBRANE FILTRATION OPERATING MODES, 2003 ($ MILLIONS)	79
TABLE 22 U.S. MEMBRANE FILTRATION CONFIGURATIONS MARKET VALUE, 2003 ($ MILLIONS)	81
TABLE 23 CONFIGURATION ADVANTAGES IN BIOTECHNOLOGY	82
TABLE 24 U.S. MARKET VALUE OF MEMBRANE FILTRATION, BY PROCESSING TYPE, 2003 ($ MILLIONS)	84
TABLE 25 U.S. MARKET VALUE OF MEMBRANE FILTRATION BIOTECH SUPPLIERS TIERS, 2003 ($ MILLIONS)	89
TABLE 26 U.S. MARKET VALUE OF ELECTROPHORESIS IN BIOTECHNOLOGY, THROUGH 2008 ($ MILLIONS)	96
TABLE 27 U.S. BIOTECH ELECTROPHORESIS APPLICATIONS MARKET VALUE, 2003 ($ MILLIONS)	103
TABLE 28 U.S. BIOTECH ELECTROPHORESIS SUPPLIERS MARKET VALUE, 2003 ($ MILLIONS)	111
TABLE 29 U.S. MARKET VALUE OF NICHE BIOTECH SEPARATION TECHNOLOGIES, THROUGH 2008 ($ MILLIONS)	120
TABLE 30 U.S. MARKET VALUE OF BIOTECH MICROARRAY SEPARATIONS, THROUGH 2008 ($ MILLIONS)	122
TABLE 31 U.S. MARKET VALUE OF BIOTECH LC/MS HYBRID SYSTEMS, THROUGH 2008 ($ MILLIONS)	134
TABLE 32 U.S. MARKET VALUE OF BIOTECH SPINNING SYSTEMS, THROUGH 2008 ($ MILLIONS)	143
TABLE 33 U.S. MARKET VALUE OF BIOTECH MAGNETIC SEPARATIONS, THROUGH 2008 ($ MILLIONS)	149
TABLE 34 TYPICAL SFC MOBILE PHASES	154
TABLE 35 U.S. MARKET VALUE OF BIOTECH SFC, THROUGH 2008 ($ MILLIONS)	155
TABLE 36 SELECTED MOLECULAR SEPARATIONS NEEDED IN BIOTECHNOLOGY	158
TABLE 37 APPARENT DIMENSIONS OF SMALL PARTICLES	160
LIST OF FIGURES
SUMMARY FIGURE:
U.S. SEPARATIONS FOR BIOTECHNOLOGY MARKET VALUE, THROUGH 2008 ($ MILLIONS)	XXIII
FIGURE 1 U.S. BIOTECH SEPARATIONS MARKET SHARES BY GEOGRAPHICAL REGION, 2003 (%)	2
FIGURE 2 U.S. BIOTECH SEPARATIONS MARKET SHARES BY TYPE, 2003	4
FIGURE 3 U.S. BIOTECH LC TECHNIQUES MARKET SHARES, BY TYPE, 2003	5
FIGURE 4 U.S. BIOTECH CENTRIFUGATION MARKET SHARES BY TYPE, 2003 (%)	7
FIGURE 5 U.S. BIOTECH MEMBRANE FILTRATION MARKET SHARES BY TYPE, 2003	9
FIGURE 6 U.S. BIOTECH ELECTROPHORESIS MARKET SHARES BY TYPE, 2003 (%)	10
FIGURE 7 U.S. BIOTECH NICHE SEPARATION TECHNOLOGIES MARKET SHARES BY TYPE, 2003 (%)	12
FIGURE 8 GENERAL SCHEME OF A BIOTECH SEPARATION	15
FIGURE 9 U.S. MARKET SHARES OF BIOTECH CHROMATOGRAPHY MODES, 2003 (%)	24
FIGURE 10 U.S. MARKET SHARES OF BIOTECH LC PROCESS DEVELOPMENTS, 2003	26
FIGURE 11 U.S. MARKET SHARES OF BIOTECH CHROMATOGRAPHIC APPLICATIONS, 2003	28
FIGURE 12 U.S. MARKET SHARES OF BIOTECH CHROMATOGRAPHY SUPPLIERS, 2003 (%)	40
FIGURE 13 U.S. MARKET SHARE OF BIOTECH CENTRIFGUATION APPLICATIONS, 2003 (%)	62
FIGURE 14 U.S. MARKET SHARE OF U.S. BIOTECH CENTRIFUGE SUPPLIERS, 2003	67
FIGURE 15 U.S. MARKET SHARE OF MEMBRANE FILTRATION PROCESS SIZES, 2003 (%)	77
FIGURE 16 U.S. MARKET SHARE OF MEMBRANE FILTRATION OPERATING MODES, 2003 (%)	79
FIGURE 17 U.S. MARKET SHARE OF MEMBRANE FILTRATION CONFIGURATIONS, 2003 (%)	81
FIGURE 18 U.S. MARKET SHARE OF MEMBRANE FILTRATION, BY PROCESSING TYPE, 2003 (%)	83
FIGURE 19 U.S. MARKET SHARE OF BIOTECH MEMBRANE FILTRATION SUPPLIERS, 2003 (%)	88
FIGURE 20 SCHEMATIC OF AN ELECTROPHORESIS SEPARATION CELL	97
FIGURE 21 U.S. MARKET SHARE OF BIOTECH ELECTROPHORESIS APPLICATIONS, 2003 (%)	103
FIGURE 22 U.S. MARKET SHARE OF BIOTECH ELECTROPHORESIS SUPPLIERS, 2003 (%)	110

Separation Systems for Commercial Biotechnology (report)

Report Details:

Publisher:

bccresearch

Type:

Market Study - October 2003

TABLE OF CONTENTS

LIST OF TABLES

LIST OF FIGURES